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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Published on: February 7, 2021

D-Peptide Engineered Double-Network Hydrogels for Synergistic Infection Control and Tumor Therapy.

Tingyuan Tan¹, Yu Tian², Deliang Zhu¹

¹Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.

Biomacromolecules

|March 6, 2026

Summary

This summary is machine-generated.

This study presents D-peptide modified double-network (DN) hydrogels that combat drug-resistant infections and tumors. These advanced biomaterials offer a promising dual therapeutic approach for complex clinical challenges.

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Area of Science:

Biomaterials Science
Drug Delivery
Nanotechnology

Background:

Drug-resistant infections and malignant tumors present significant clinical challenges.
Multifunctional biomaterials are needed for integrated therapeutic efficacy.

Purpose of the Study:

To develop D-peptide engineered double-network (DN) hydrogels with combined antibacterial and antitumor properties.
To evaluate the mechanical stability and therapeutic efficacy of these novel hydrogels.

Main Methods:

Fabrication of DN hydrogels using GelMA and a bioactive D-peptide (ik3).
Assessment of hydrogel toughness, stability, and proteolytic resistance.
In vitro evaluation of antibacterial activity against Gram-negative and Gram-positive bacteria.
In vitro assessment of tumor cell apoptosis induction.

Main Results:

DN architecture enhanced hydrogel toughness and stability under physiological conditions.
The incorporated ik3 peptide demonstrated broad-spectrum antibacterial properties.
Significant inhibition of bacterial growth and induction of tumor cell apoptosis were observed.
Sustained bioactivity of the D-peptide was confirmed.

Conclusions:

D-peptide modified DN hydrogels represent a promising multifunctional platform.
These hydrogels offer synergistic capabilities for infection control and tumor therapy.
The developed biomaterial holds potential for addressing complex clinical challenges posed by co-existing infections and tumors.