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Published on: November 21, 2025
Prognostic Value of Selective Nerve Root Blocks Prior to Pulsed Radiofrequency in the Treatment of Patients With
Marius R van Ooijen1, Sezai Özkan1, Koen van Boxem2
1Department of Anesthesiology, Pain and Palliative Medicine, Radboudumc, Nijmegen, the Netherlands.
Background/Importance:
Selective nerve root blocks (SNRBs) are frequently used in clinical algorithms for managing chronic radicular pain. However, their prognostic value in identifying patients likely to benefit from pulsed radiofrequency (PRF) treatment remains uncertain.
Objective:
This systematic review evaluates whether a positive response to an SNRB predicts improved clinical outcomes following PRF in patients with chronic radicular pain.
Evidence Review:
A systematic search was conducted in PubMed, Embase, and Cochrane databases, along with reference lists of relevant articles. Eligible studies included patients with chronic radicular pain and assessed the prognostic role of SNRBs administered prior to PRF. Risk of bias was assessed using the ROBINS-I V2 tool.
Results:
Only one prospective observational study met inclusion criteria. In patients with chronic lumbosacral radicular pain, a positive SNRB response was associated with a higher likelihood of treatment success at 6-week follow-up (odds ratio: 3.26; 95% CI: 0.97-11.00; p = 0.06). Multivariate analysis identified limited baseline disability, age > 55 years, and a positive SNRB response as predictors of success at 6 months, with an area under the receiver operating characteristic curve of 0.73.
Conclusions:
This review identified a lack of published studies-aside from one prospective observational study-examining the prognostic value of SNRBs in the context of PRF for chronic radicular pain. The findings underscore not only a lack of high-quality evidence but a broader gap in the literature. Further robust research is warranted to clarify the clinical utility of SNRBs in guiding PRF treatment decisions.
