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Updated: Mar 7, 2026

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection
Published on: August 26, 2011
Subtle alterations of autobiographical memory and spatiotemporal processing in subjective cognitive decline
Matilde Conti1,2, Alice Teghil1,3, Maria Schettino1
1Department of Psychology, Sapienza University of Rome, Rome, Italy.
Subtle changes in autobiographical memory and spatial-temporal processing occur in Subjective Cognitive Decline (SCD), a preclinical stage of Alzheimer's Disease. Cognitive complaints influence these memory and processing alterations.
Area of Science:
- Neuroscience
- Cognitive Psychology
Background:
- Alzheimer's Disease (AD) is characterized by memory and consciousness decline.
- Subjective Cognitive Decline (SCD) is a preclinical AD stage with self-reported cognitive issues but no objective impairment.
Purpose of the Study:
- Investigate autobiographical memory (AM) alterations in SCD.
- Examine spatial and temporal processing in SCD.
- Assess the impact of cognitive complaints on AM and processing in SCD.
Main Methods:
- Compared 31 SCD individuals with 31 matched healthy controls.
- Assessed AM using Autobiographical Interview and Fluency Task (AFT).
- Evaluated environmental navigation and duration processing.
- Measured cognitive complaints using the Cognitive Failure Questionnaire.
Main Results:
- SCD individuals showed more semantic AFT items but poorer landmark recognition and survey knowledge than controls.
- Cognitive complaints correlated positively with semantic AFT performance.
- Cognitive complaints correlated negatively with retrospective duration processing.
Conclusions:
- Subtle alterations in AM and spatiotemporal processing are detectable in SCD.
- Cognitive complaints significantly modulate AM and spatiotemporal processing in SCD individuals.
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