Early Recurrent Hepatocellular Carcinoma with CK19 Positive Receiving Transarterial Chemoembolization After Surgical...

Area of Science:

• Hepatobiliary surgery
• Oncology
• Medical imaging and diagnostics

Background:

• Hepatocellular carcinoma (HCC) recurrence post-hepatectomy poses significant challenges.
• CK19 expression is a key factor in predicting HCC recurrence and outcomes.
• Transarterial chemoembolization (TACE) is a common treatment for recurrent HCC.

Purpose of the Study:

• To evaluate a nomogram-based model for predicting response and survival in early recurrent HCC patients with CK19 positivity.
• To identify independent prognostic factors for risk stratification.
• To assess the predictive efficacy of the developed nomogram.

Main Methods:

• Retrospective analysis of 82 patients with CK19-positive recurrent HCC post-hepatectomy treated with TACE.
• Kaplan-Meier analysis and Log-rank test for Overall Survival (OS) and Progression-Free Survival (PFS).
• COX regression to identify predictors, followed by nomogram construction and validation using ROC curves and calibration plots.

Main Results:

• CK19 expression grade and distant metastasis were independent risk factors for HCC recurrence.
• Number of TACE sessions and combination with systemic therapy were protective factors.
• The nomogram demonstrated promising predictive efficacy, with combined TACE showing survival benefits over TACE alone for CK19-positive recurrence.

Conclusions:

• A validated nomogram tool for predicting prognosis in postoperative recurrent HCC patients was developed.
• The model aids in identifying recurrence risk levels and optimizing early clinical treatment.
• The tool aims to improve patient survival benefits through precise risk assessment and tailored therapy.