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Published on: March 30, 2014
Adherence to Nevirapine Prophylaxis and Its Predictors Among HIV-Exposed Infants Aged 0 to 6 months in Western
Peterson Amumpaire1, Martin Tugume1, Samson Udho1
1Lira University, Uganda.
Insights
Adherence to Nevirapine prophylaxis among HIV-exposed infants in Western Uganda was 95.0%. Key predictors of adherence included HIV status disclosure and having multiple children, highlighting areas for improved HIV prevention strategies.
Area of Science:
- Public Health
- Pediatrics
- Infectious Diseases
Background:
- HIV transmission from mother to child remains a global health concern.
- Uganda faces challenges with nearly 7% of infants born to HIV-positive mothers acquiring the virus.
- Limited data exists on Nevirapine adherence in Western Uganda for HIV-exposed infants.
Purpose of the Study:
- To determine the adherence rate to Nevirapine prophylaxis in HIV-exposed infants aged 0-6 months in Western Uganda.
- To identify factors predicting adherence to Nevirapine prophylaxis in this population.
Main Methods:
- A cross-sectional study was conducted with 200 HIV-exposed infants (0-6 months).
- Participants were recruited consecutively.
- Data analysis involved logistic regression to identify predictors of Nevirapine adherence.
Main Results:
- Nevirapine prophylaxis adherence was 95.0% (CI: 89-98%).
- Factors significantly associated with adherence included disclosure of maternal HIV status (aOR=0.083) and having more than one child (aOR=0.08).
- Adherence fell short of the national goal of 100%.
Conclusions:
- While adherence to Nevirapine prophylaxis is high, it is not optimal in Western Uganda.
- HIV status disclosure and family size are significant predictors of adherence.
- Interventions should consider these factors to improve Nevirapine prophylaxis adherence and reduce infant HIV transmission.
Abstract:
HIV remains a global public health issue; Uganda has nearly 7% of infants born to HIV positive mothers getting infected despite initiation on Nevirapine prophylaxis against HIV transmission among HIV-exposed infants. There is paucity of data regarding adherence to NVP in Western Uganda. This study aimed at assessing the predictors of adherence to nevirapine prophylaxis among HIV -exposed infants aged 0 to 6 months. A cross-sectional study was done among 200 HIV-exposed infants aged 0 to 6 months. Participants were consecutively recruited. Data was analyzed using SPSS version 26, logistic regression was used to infer predictors of Nevirapine adherence. Adherence to Nevirapine prophylaxis was at 95.0% (CI: 89-98). Factors associated with adherence included; disclosure of HIV status [aOR = 0.083; 95% CI: 0.007-0.92, P < .005] and having more than 1 child [aOR = 0.08; 95% CI: 0.007-0.82, P < .005]. Adherence to Nevirapine was suboptimal (95.0%) in comparison to the national set goals of 100% adherence by 2030.
