Lack of association between the Catalase rs1001179 (-262 C > T) promotor polymorphism and diabetic nephropathy: a...

This meta-analysis aimed to comprehensively assess the association between the CAT rs1001179 (- 262 C > T) polymorphism and the risk of developing diabetic nephropathy (DN).

A systematic literature search was conducted in PubMed, Scopus, and Web of Science up to December 31, 2025. Eligible studies included case-control or cohort designs evaluating rs1001179 variant in relation to DN risk. Data were synthesized as odds ratios (ORs) with 95% confidence intervals (CIs) under multiple genetic models. Between-study heterogeneity was assessed using Cochran's Q test and the I² statistic. Sensitivity analyses, including restriction to datasets whose control groups conformed to Hardy-Weinberg equilibrium (HWE), were performed to evaluate result robustness.

Seven publications comprising eight independent datasets were included. Across all genetic models, no significant association was observed between rs1001179 and DN risk in the overall analysis. Consistent null results were also obtained in subgroup analyses stratified by diabetes type and in sensitivity analyses restricted to datasets in HWE.

This meta-analysis indicates that rs1001179 variant is not significantly associated with susceptibility to DN. Despite its biological plausibility in oxidative stress regulation, this variant is unlikely to independently influence DN risk.