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Pericardial Metaplastic Ossification With Widespread Bone Formation: A Case Report.
B Gharia1, A Graham1, McEwen C C2
1Department of Pathology and Molecular Medicine, Hamilton General Hospital, McMaster University, Hamilton, Ontario, Canada, mcmaster.ca.
Case Reports in Pathology
|March 6, 2026
Summary
Extensive pericardial ossification, a rare cause of constrictive pericarditis (CP), was identified in a male patient. Early pericardiectomy surgery is crucial for a good outcome in CP cases.
Area of Science:
- Cardiology
- Pathology
Background:
- Pericardial disease encompasses conditions like acute pericarditis, pericardial effusion, cardiac tamponade, and constrictive pericarditis (CP).
- Pericardial calcification occurs in less than 25% of CP cases, increasing the risk of cardiac complications.
Purpose of the Study:
- To report a rare case of extensive pericardial ossification presenting as pericardial effusion.
- To highlight the importance of considering rare causes of pericardial disease for timely diagnosis and intervention.
Main Methods:
- Case report of a 65-year-old male with recurrent pericardial effusion.
- Diagnostic workup included echocardiogram revealing diastolic dysfunction and constrictive physiology.
- Surgical intervention involved bilateral anterior pericardiectomy with histological examination of pericardial tissue.
Main Results:
- The patient was diagnosed with constrictive pericarditis (CP) and managed medically, later undergoing surgery due to worsening symptoms.
- Histological analysis confirmed extensive pericardial ossification with bone formation in adipose tissue.
- Cytology of pericardial fluid was negative for malignancy.
Conclusions:
- Idiopathic pericardial ossification is a rare entity that can lead to CP.
- Prompt diagnosis and surgical intervention, such as pericardiectomy, are associated with favorable outcomes in CP.
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