Association Between Inflammatory Cytokines and Systemic Inflammation Indices in Patients With Psoriasis: A...

Area of Science:

• Dermatology
• Immunology
• Hematology

Background:

• Systemic inflammation indices from complete blood counts (CBC) are accessible markers of inflammatory burden.
• The relationship between CBC-derived indices and serum cytokines in psoriasis is not well understood.

Purpose of the Study:

• To investigate the associations between CBC-derived indices and serum cytokines in patients with psoriasis.
• To explore the potential of CBC-derived indices as adjunct markers for inflammatory activity in psoriasis.

Main Methods:

• A cross-sectional study included 28 psoriasis patients and 23 healthy controls.
• Serum cytokines (IL-17, IL-22, IL-23, IL-31, IL-33, IL-36, TNF-α, TGF-β, IFNγ) were quantified using ELISA.
• CBC-derived indices including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV) were computed.

Main Results:

• Psoriasis patients exhibited significantly higher levels of all measured cytokines and higher SIRI compared to controls.
• PIV showed a nominal difference between groups that did not reach statistical significance after correction for multiple comparisons.
• While SIRI and PIV demonstrated the most consistent directional co-variation with cytokines, these associations were modest and require further validation.

Conclusions:

• SIRI was consistently elevated in psoriasis patients, suggesting its potential as a marker.
• Exploratory analyses indicated modest associations between SIRI, PIV, and cytokines, warranting further investigation.
• These hypothesis-generating findings support larger cohort studies to validate CBC-derived indices as scalable adjunct markers for psoriasis inflammatory activity.