Multi-Omics Mechanisms of Trimethylamine Oxide and Cardiovascular Disease: A Review

Area of Science:

• Microbiome research
• Cardiovascular science
• Metabolomics

Background:

• Cardiovascular diseases (CVDs) are a leading global health concern.
• Existing CVD therapies have limitations, with high recurrence and mortality rates.
• The gut microbiome and its metabolites are increasingly recognized as key players in CVD pathogenesis.

Purpose of the Study:

• To review the role of trimethylamine N-oxide (TMAO) in various cardiovascular diseases.
• To compare TMAO-related mechanisms across different CVDs using a multi-omics approach.
• To evaluate TMAO's potential as a biomarker and therapeutic target for CVDs.

Main Methods:

• Literature review
• Multi-omics data analysis
• Pathogenic network construction

Main Results:

• TMAO, a gut microbiota metabolite, is implicated in CVD development and progression.
• Common and distinct TMAO-driven mechanisms exist across different cardiovascular conditions.
• A TMAO-driven pathogenic network provides insights into CVD etiology.

Conclusions:

• TMAO represents a significant link between gut microbiota and cardiovascular health.
• TMAO holds translational potential as a biomarker and therapeutic target for CVDs.
• Further research is needed to overcome challenges in clinical applications of TMAO.