Lactylation, Crotonylation and Succinylation: Decoding Their Roles in the Progression of Cardiovascular Disease

Area of Science:

• Biochemistry
• Molecular Biology
• Cardiovascular Research

Background:

• Cardiovascular diseases (CVDs) pose a significant global health threat, with underlying molecular mechanisms still under investigation.
• Epigenetic modifications, particularly post-translational modifications (PTMs), are increasingly recognized for their role in CVD pathogenesis.
• Traditional PTMs like phosphorylation and acetylation are linked to CVDs, but novel acylation modifications are emerging.

Purpose of the Study:

• To review the mechanisms of novel acylation modifications in the development of cardiovascular diseases.
• To highlight the role of crotonylation, lactylation, and succinylation in CVDs.
• To emphasize the importance of understanding PTMs for identifying new therapeutic targets and biomarkers for CVDs.

Main Methods:

• Review of current scientific literature on post-translational modifications and cardiovascular diseases.
• Focus on novel acylation modifications including crotonylation, lactylation, and succinylation.
• Integration of findings from high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) studies.

Main Results:

• Novel acylation modifications, including crotonylation, lactylation, and succinylation, have been identified through advanced proteomic techniques.
• These modifications represent critical regulatory mechanisms that enhance proteome diversity.
• Evidence suggests a close association between these novel PTMs and the pathogenesis of various CVDs.

Conclusions:

• Novel acylation PTMs like crotonylation, lactylation, and succinylation are implicated in the mechanisms of cardiovascular disease development.
• Further research into these modifications is crucial for elucidating CVDs' molecular basis.
• Understanding these PTMs can lead to the discovery of novel biomarkers and therapeutic strategies for CVDs.