Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Schottky Barrier Diode01:27

Schottky Barrier Diode

1.2K
Schottky barrier diodes are specialized semiconductor devices characterized by their unique construction. This construction involves combining a metal layer with a moderately doped n-type semiconductor material. This combination leads to the formation of a Schottky barrier, a pivotal element that defines the diode's operational characteristics. The core functionality of Schottky barrier diodes is their capacity to allow current to flow in only one direction due to their distinctive...
1.2K
Biasing of Metal-Semiconductor Junctions01:27

Biasing of Metal-Semiconductor Junctions

729
Biasing metal-semiconductor junctions involves applying a voltage across the junction. Specifically, the metal is connected to a voltage source, while the semiconductor is grounded. This technique is essential for controlling the direction and magnitude of current flow in electronic devices, including diodes, transistors, and photovoltaic cells.
In Schottky junctions, where the semiconductor is n-type, applying a positive voltage to the metal relative to the semiconductor reduces its Fermi...
729
Metal-Semiconductor Junctions01:24

Metal-Semiconductor Junctions

1.2K
The contact of metal and semiconductor can lead to the formation of a junction with either Schottky or Ohmic behavior.
Schottky Barriers
Schottky barriers arise when a metal with a work function (Φm) contacts a semiconductor with a different work function (Φs). Initially, electrons transfer until the Fermi levels of the metal and semiconductor align at equilibrium. For instance, if Φm > Φs, the semiconductor Fermi level is higher than the metal's before contact. The...
1.2K
Radiation: Applications01:17

Radiation: Applications

1.9K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.9K
Biasing of P-N Junction01:16

Biasing of P-N Junction

2.3K
The operation of a p-n junction diode involves various biasing conditions, including forward bias, reverse bias, and equilibrium.
In equilibrium, no external voltage is applied across the p-n junction. The depletion region is formed at the junction interface due to the diffusion of carriers, which leaves behind charged dopants, acceptors on the p-side, and donors on the n-side. These immobile charges create an electric field that prevents further diffusion of carriers. The related energy band...
2.3K
Absorption of Radiation01:05

Absorption of Radiation

1.4K
The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent advances of anticancer nanomaterial vaccine platforms.

Biomaterials science·2026
Same author

Bridging Microscopic Interfacial Water and Macroscopic Wettability for Enhanced Hydrogen Evolution Reaction.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

In situ reprogramming of CAR-alveolar macrophages via liposomal nanomedicine for lung cancer immunotherapy.

Nature communications·2026
Same author

Development and validation of a noninvasive machine learning model using urinary extracellular vesicle physical parameters for prostate cancer diagnosis.

Scientific reports·2026
Same author

Helper lipid-engineered extracellular vesicles enable PET imaging-guided pulmonary siRNA delivery to treat lung metastasis.

Science advances·2026
Same author

A glycopeptide hydrogel confers protection and treatment in sepsis via recruitment and training of macrophages.

Materials today. Bio·2026

Related Experiment Video

Updated: Mar 7, 2026

Fabrication of Schottky Diodes on Zn-polar BeMgZnO/ZnO Heterostructure Grown by Plasma-assisted Molecular Beam Epitaxy
14:16

Fabrication of Schottky Diodes on Zn-polar BeMgZnO/ZnO Heterostructure Grown by Plasma-assisted Molecular Beam Epitaxy

Published on: October 23, 2018

8.1K

A Stepwise-Enhanced Schottky Heterojunction Enables Ultra-Low-Dose Radiodynamic Therapy via Matrix Remodeling and

Chaoyi Lyu1, Yanbin Chen1, Yingyi Ning1

  • 1State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|March 6, 2026
PubMed
Summary

This study introduces a novel radiosensitizer for enhanced cancer therapy. The new material improves reactive oxygen species production and tumor penetration, enabling effective treatment with ultra-low X-ray doses.

Keywords:
heterojunction interface engineeringmetal–organic frameworkmild photothermal therapyradiodynamic therapytumor matrix remodeling

More Related Videos

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.7K
Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

12.3K

Related Experiment Videos

Last Updated: Mar 7, 2026

Fabrication of Schottky Diodes on Zn-polar BeMgZnO/ZnO Heterostructure Grown by Plasma-assisted Molecular Beam Epitaxy
14:16

Fabrication of Schottky Diodes on Zn-polar BeMgZnO/ZnO Heterostructure Grown by Plasma-assisted Molecular Beam Epitaxy

Published on: October 23, 2018

8.1K
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.7K
Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

12.3K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Radiodynamic therapy (RDT) uses reactive oxygen species (ROS) to enhance radiotherapy, but efficiency is limited by electron-hole recombination and poor nanoparticle penetration.
  • Nanoscale metal-organic frameworks (nMOFs) show promise for RDT but face challenges with electron-hole recombination and tumor matrix barriers.

Purpose of the Study:

  • To develop a novel radiosensitizer combining heterojunction engineering with nMOFs for improved RDT efficacy.
  • To overcome limitations of electron-hole recombination and tumor matrix penetration in nMOF-based RDT.

Main Methods:

  • Fabrication of a Hf-TCPP/Nb2C@PEG Schottky heterojunction (HTNCP) for RDT.
  • Utilizing Nb2C for enhanced electron-hole separation and photothermal matrix degradation.
  • Sequential treatment with a 1064 nm laser and low-dose X-ray irradiation.

Main Results:

  • HTNCP significantly boosted superoxide radical and singlet oxygen production by 2.64-fold due to improved electron-hole separation.
  • Mild photothermal effect degraded the collagen matrix, promoting HTNCP self-penetration into tumors.
  • Suppressed triple-negative breast cancer tumor growth and metastasis in mice using ultra-low X-ray doses (1 Gy × 5).

Conclusions:

  • The developed HTNCP radiosensitizer demonstrates superior RDT efficacy by enhancing ROS production and tumor penetration.
  • This study presents a novel sequential treatment strategy combining matrix degradation with RDT for effective clinical tumor radiotherapy.