Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chirality in Nature02:30

Chirality in Nature

17.5K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
17.5K
Prochirality02:05

Prochirality

5.2K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
5.2K
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

7.2K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
7.2K
SN1 Reaction: Stereochemistry02:15

SN1 Reaction: Stereochemistry

10.7K
This lesson provides an in-depth discussion of the stereochemical outcomes in an SN1 reaction.
In the first step of an SN1 reaction, the bond between the electrophilic carbon and the leaving group ionizes to generate the carbocation intermediate. The second step of the mechanism is the nucleophilic attack.
In the formed carbocation, the positively charged carbon is sp2 hybridized with a trigonal planar geometry. As all the three substituents lie on the same plane, a plane of symmetry for the...
10.7K
Chirality02:25

Chirality

31.0K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
31.0K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

15.9K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
15.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chiral-Induced Spin Selectivity Effect in a 1 nm Thin 1,1'-Binaphthyl-2,2'-diyl Hydrogenphosphate Self-Assembled Monolayer on Nickel Oxide.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Enantiospecific Magnetoconductance Asymmetry in a Racemic Conglomerate Driven by Surface-Assisted Symmetry Breaking.

Journal of the American Chemical Society·2026
Same author

Close-Shell and Biradical Enantiomers for Probing the Chiral-Induced Spin Selectivity Effect.

The journal of physical chemistry letters·2026
Same author

Dynamic breaking of mirror symmetry in spin-dependent electron transport through chiral media causes enantiomeric excesses.

Science advances·2026
Same author

Temperature-Enhanced Coercive Field by Chiral Molecules.

The journal of physical chemistry letters·2026
Same author

The Effects of Surface Spin Polarization on Copper Oxidation by Triplet Oxygen.

ACS nano·2026

Related Experiment Video

Updated: Mar 7, 2026

Experimental Methods for Spin- and Angle-Resolved Photoemission Spectroscopy Combined with Polarization-Variable Laser
09:00

Experimental Methods for Spin- and Angle-Resolved Photoemission Spectroscopy Combined with Polarization-Variable Laser

Published on: June 28, 2018

10.6K

Why Is the Mechanism Underlying the Chiral-Induced Selectivity Effect Still Challenging?

Ron Naaman1, Yossi Paltiel2

  • 1Department of Chemical and Biological Physics, Weizmann Institute, Rehovot, Israel.

Advanced Materials (Deerfield Beach, Fla.)
|March 6, 2026
PubMed
Summary
This summary is machine-generated.

Theorists find it difficult to explain the chiral-induced spin selectivity (CISS) effect due to its unique spin-dependent transport in chiral systems, differing from standard electron transfer theories. New experiments highlight missing elements in current models.

Keywords:
CISSchiralitypolarizabilityspintime reversal symmetry

More Related Videos

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

11.0K
Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

11.1K

Related Experiment Videos

Last Updated: Mar 7, 2026

Experimental Methods for Spin- and Angle-Resolved Photoemission Spectroscopy Combined with Polarization-Variable Laser
09:00

Experimental Methods for Spin- and Angle-Resolved Photoemission Spectroscopy Combined with Polarization-Variable Laser

Published on: June 28, 2018

10.6K
Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

11.0K
Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

11.1K

Area of Science:

  • Condensed matter physics
  • Quantum chemistry
  • Materials science

Background:

  • The chiral-induced spin selectivity (CISS) effect describes spin-polarized currents generated by chiral molecules.
  • Existing theories often model electron transport through linear systems, which may not fully capture chiral phenomena.

Purpose of the Study:

  • To elucidate the theoretical challenges in developing a comprehensive mechanism for the CISS effect.
  • To highlight the distinctions between spin-dependent transport in chiral systems and conventional electron transfer theories.

Main Methods:

  • This work is a perspective, analyzing existing theories and experimental data.
  • It identifies gaps in current theoretical frameworks for electron transfer.
  • It references experimental findings that underscore the importance of specific physical elements.

Main Results:

  • Theoretical models struggle with the CISS effect because they often overlook key aspects of spin-dependent transport unique to chiral environments.
  • Spin transport through chiral systems exhibits distinct characteristics compared to linear systems.
  • Experiments confirm the necessity of considering specific, currently missing, theoretical elements.

Conclusions:

  • A comprehensive mechanism for the CISS effect requires incorporating elements beyond conventional electron transfer theories.
  • Understanding these missing elements is crucial for advancing theoretical descriptions of spin-dependent phenomena in chiral materials.
  • Further theoretical development is needed to fully explain the CISS effect and its experimental observations.