Related Experiment Video
Updated: Mar 7, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
975
Advances and Ongoing Challenges in Colorectal Cancer
Chirurgia (Bucharest, Romania : 1990)
|March 6, 2026
Summary
Colorectal cancer (CRC) management has advanced with new screening, molecular profiling, and surgical techniques. Challenges like resistance and early-onset CRC persist, requiring precision medicine and microbiome strategies for future progress.
Area of Science:
- Oncology
- Gastroenterology
- Genetics
Background:
- Colorectal cancer (CRC) presents a significant global health challenge with increasing incidence in younger populations and high mortality in advanced stages.
- Etiology is complex, involving lifestyle, genetics, inflammation, and gut microbiome dysbiosis.
Purpose of the Study:
- To review recent advances in colorectal cancer management, covering epidemiology, molecular pathways, screening, diagnostics, surgery, and therapies.
- To synthesize evidence from 2015-2025 to identify current progress and future directions in CRC care.
Main Methods:
- A comprehensive narrative review of literature from PubMed/MEDLINE, Scopus, and Web of Science (January 2015 - June 2025).
- Selection of peer-reviewed articles on CRC epidemiology, molecular pathways, screening, diagnostics, surgical management, systemic therapies, and emerging treatments.
- Qualitative synthesis and thematic organization of evidence.
Main Results:
- Screening advancements (endoscopic imaging, fecal DNA, blood biomarkers) improve early detection, though implementation varies.
- Molecular profiling (MSI-H/dMMR, RAS/RAF, HER2) guides personalized therapy and prognosis.
- Minimally invasive surgery enhances safety and reduces morbidity; advanced techniques and multimodal strategies expand options for complex cases.
Conclusions:
- Despite progress in screening, molecularly guided therapies, and surgical techniques, challenges like therapeutic resistance, tumor heterogeneity, and rising early-onset CRC remain.
- Future CRC management will likely focus on precision medicine, ctDNA monitoring, microbiome-targeted strategies, and optimized surgical selection.
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