Related Experiment Video

Updated: Mar 7, 2026

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

15.1K

[Retracted] Design, synthesis and preclinical evaluation of NRC‑AN‑019

Kompella Amala1, A K S Bhujanga Rao1, Bharathi Gorantla2

  • 1Natco Research Centre, Sanath Nagar, Hyderabad 500-018, India.

International Journal of Oncology
|March 6, 2026
PubMed

Insights

This study on experimental mice was retracted due to duplicated images in luciferase imaging experiments. The journal lost confidence in the presented data following concerns about data duplication and lack of author response.

Area of Science:

  • Oncology
  • Biomedical Research
  • Scientific Publishing Ethics

Background:

  • A previously published paper in the International Journal of Oncology faced scrutiny regarding its experimental data.
  • Concerns were raised by a reader about the duplication of images depicting experimental mice.

Purpose of the Study:

  • To address concerns regarding potential data duplication and image manipulation in a published study.
  • To maintain scientific integrity and reader confidence in published research.

Main Methods:

  • Review of images (Figs. 4A and 5A) from the experimental study.
  • Assessment of mouse positioning and luciferase imaging details for data consistency.

Main Results:

  • Identification of several sets of mice in unexpectedly similar orientations across different data sets.
  • Detection of significant data duplication within the paper.

Conclusions:

  • The paper was retracted from the International Journal of Oncology due to a lack of confidence in the presented data.
  • The retraction was issued following the identification of data duplications and the authors' failure to respond to editorial inquiries.
Keywords:
BCR-ABLNRC-AN-019chronic myeloid leukemiaimatinibleukemiatyrosine kinase inhibitor

More Related Videos

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

12.0K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

1.0K

Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
6.2K
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
275