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Research progress in single‑cell omics technologies for kidney disease (Review)
Jia Xu1, Ziwei Chen2, Shengyao Li3
1Hospital of Chengdu University of Traditional Chinese Medicine, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, P.R. China.
Single-cell omics technologies reveal kidney cell diversity and immune cell dynamics in renal ageing and disease. This approach aids in understanding disease mechanisms and identifying new therapeutic targets for kidney disorders.
Area of Science:
- Nephrology
- Immunology
- Genomics
Background:
- The kidney's complex cellular structure, including diverse specialized cells, poses challenges for studying kidney diseases.
- Understanding renal cell heterogeneity is crucial for advancing kidney research.
Purpose of the Study:
- To review the applications of single-cell omics in renal ageing and kidney diseases.
- To highlight how these technologies elucidate immune cell roles and interactions in the kidney.
Main Methods:
- Application of single-cell omics technologies.
- Analysis of renal cell diversity and heterogeneity.
- Identification and characterization of immune cell populations in the kidney.
Main Results:
- Single-cell omics have uncovered extensive renal cell diversity and heterogeneity.
- Precise identification of various immune cell types within the kidney is now possible.
- Dynamic changes in renal immune cells during disease progression have been elucidated.
Conclusions:
- Single-cell omics provide powerful tools for dissecting kidney disease pathogenesis.
- These technologies offer insights into immune cell dynamics and interactions in renal disorders.
- This research lays the foundation for identifying novel therapeutic targets in kidney diseases.
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