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Updated: Mar 7, 2026
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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
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A Clinical Approach to Establishing Normative Data in Pediatric OCT Angiography.
Michal Koubek1,2,3, Jan Studnicka3,4,5, Juraj Timkovic1,2
1Faculty of Medicine, University of Ostrava, Ostrava, Czechia.
Journal of Pediatric Ophthalmology and Strabismus
|March 6, 2026
Summary
Optical coherence tomography angiography (OCTA) reveals no age-related changes in vascular density or foveal avascular zone in children. However, adolescent capillary width in the choriocapillaris does change, highlighting developmental vascular differences.
Area of Science:
- Ophthalmology
- Pediatric Medicine
- Medical Imaging
Background:
- Pediatric retinal vascular parameters are not well-established.
- Optical coherence tomography angiography (OCTA) offers detailed vascular imaging.
- Understanding pediatric vascular development is crucial for diagnosing eye conditions.
Purpose of the Study:
- To evaluate vascular parameters in children and adolescents using OCTA.
- To compare pediatric OCTA data with adult normative values.
- To assess the impact of development on pediatric vascular parameters.
Main Methods:
- 150 healthy children (6-15 years) underwent wide-field OCTA.
- Vascular density and foveal avascular zone size were calculated using ImageJ and OCTAVA macro.
- Data were analyzed for age-related correlations in central and peripheral scans.
Main Results:
- No significant correlation found between age and vascular density in children.
- No direct correlation observed between age and foveal avascular zone size.
- Capillary width in the choriocapillaris demonstrated changes during adolescence.
Conclusions:
- Establishing normative OCTA databases for children is essential.
- This aids in diagnosing and characterizing pediatric vascular pathologies.
- Developmental changes in the choriocapillaris are noted during adolescence.
