Multifocal Digital Squamous Cell Carcinoma With Sarcoma Differentiation: A Case Report

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Sarcomatoid squamous cell carcinoma (SCC) is a rare, aggressive skin cancer subtype.
• It is characterized by highly invasive biological features, leading to a poor prognosis, especially in skin presentations.
• Digital SCC, particularly the sarcomatoid variant, presents unique challenges in diagnosis and management.

Purpose of the Study:

• To report a rare case of multifocal digital sarcomatoid SCC in a 48-year-old male.
• To highlight the clinical presentation, diagnostic challenges, and aggressive nature of this condition.
• To emphasize the importance of early intervention and extensive management strategies.

Main Methods:

• Case report of a patient with multiple primary SCCs and a digital sarcomatoid tumor.
• Diagnostic procedures included imaging studies and pathological biopsies.
• Treatment involved surgical excision and photodynamic therapy.

Main Results:

• The patient presented with multiple SCCs on both hands and a sarcomatoid tumor on the right third finger.
• Pathological findings confirmed moderately differentiated SCC involving multiple digits.
• Despite treatment, local recurrence occurred within 3 months, and the patient was lost to follow-up.

Conclusions:

• Multifocal digital sarcomatoid SCC is highly aggressive and challenging to diagnose.
• Early intervention, extensive resection, and close follow-up are essential for managing digital sarcomatoid SCC.
• This case underscores the need for prompt and comprehensive treatment to improve patient outcomes in aggressive digital SCC.