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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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HIV-associated lymphoproliferative disorders: Single-center experience.

Derya Demirtas1, Tayfur Toptas1, Asu Fergun Yilmaz1

  • 1Division of Hematology, University of Marmara, Istanbul, Turkey.

Medicine
|March 6, 2026
PubMed
Summary
This summary is machine-generated.

Combination antiretroviral therapy (cART) alongside anti-tumor treatments significantly improves survival and response rates for patients with acquired immune deficiency syndrome (AIDS)-related lymphoma. This study highlights favorable outcomes in aggressive lymphoma cases.

Keywords:
AIDS-related lymphomasacquired immune deficiency syndromecombination antiretroviral therapyhuman immunodeficiency virusimmunodeficiencylymphoproliferative diseases

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Hematology

Background:

  • Survival rates for human immunodeficiency virus (HIV)-positive individuals have improved due to advancements in lymphoma treatments and combination antiretroviral therapy (cART).
  • Acquired immune deficiency syndrome (AIDS)-related lymphoma remains a significant clinical challenge, necessitating evaluation of current treatment strategies.

Purpose of the Study:

  • To present demographic and clinical characteristics, prognosis, and survival data of AIDS-related lymphoma patients from a single-center experience.
  • To assess the impact of combined anti-tumor treatments and cART on survival and response rates.

Main Methods:

  • Retrospective review of 16 AIDS-related lymphoma patients treated between August 2010 and March 2022.
  • Analysis of demographic data, clinical information, treatment details, and survival outcomes.
  • Evaluation of treatment response in patients who completed initial therapy.

Main Results:

  • The study included 15 males with a median age of 46.5 years, presenting with various lymphoma subtypes, predominantly at advanced stages.
  • Eleven out of 16 patients (68.8%) achieved complete response and are still alive.
  • Diagnosis of AIDS preceded lymphoma in 11 patients, with a median time from HIV infection to lymphoma diagnosis of 23.8 months.

Conclusions:

  • Combination antiretroviral therapy (cART) administered concurrently with anti-tumor treatments demonstrates a favorable impact on survival and response rates in patients with AIDS-related lymphoma.
  • These findings underscore the efficacy of integrated treatment approaches for this aggressive patient group.