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Updated: Mar 8, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Hyaluronic acid-based control/target delivery system: Formation, control release and applications
Yanhong Luo1, Liangbin Wang1, Guanghui Li1
1Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Key Laboratory of Green Processing and Intelligent Manufacturing of Lingnan Specialty Food, Ministry of Agriculture, Guangzhou 510225, China; College of Light Industry and Food Sciences, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
None:
Hyaluronic acid (HA), a natural bioactive polysaccharide, has emerged as a core material in interdisciplinary bioactive delivery systems due to its excellent biocompatibility, shear-thinning properties, and CD44 receptor targeting capability. This review summarizes the design, controlled-release, and applications of HA-based systems. In biomedicine, HA carriers enable targeted cancer therapy and bone defect repair. Responsive 3D-printed hydrogels support targeted drug delivery and bone regeneration. HA microneedles and nanoemulsions enhance transdermal absorption of actives. Injectable hydrogels provide long-term soft tissue augmentation, indicating nutraceutical potential. In the food industry, HA-gelatin layer-by-layer (LbL) microcapsules improve probiotic antioxidant capacity and survival. HA-based Pickering emulsions also enhance curcumin stability, digestibility, and bioavailability. Future developments focus on "goalkeeper"-style multifunctional smart HA synergistic delivery systems and localized/sustained gene delivery, and safety assessments for new HA-based systems also require careful consideration.
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