Multifunctional carrier based on biocompatible artificial anionic polysaccharide, cross-linked with ⁹⁰Y(III) ions and...

For ⁹⁰Y obtained on a⁹⁰Sr/⁹⁰Y generator, a microgel based on carboxymethyl cellulose (CMC) is proposed as a multifunctional carrier platform for the radionuclide and the antitumor agent. Both binary (CMC-⁹⁰Y[Y] and CMC-⁹⁰Y) and ternary (⁹⁰Y[Y]-CMC-NO-synthase effector) microgels with different yttrium contents were synthesized and characterized. Both direct synthesis and isotope exchange used for the introduction of the radionuclide. In both cases, the degree of introduction was maximal. It was found that the size of the microgels and their cytotoxicity depend on the yttrium content, especially in the case of ternary (i.e. containing an organic component) microgels. This dependence is a result of changes in the structure of the formed particles and is confirmed by the data obtained by light scattering (D_h) and electrophoretic mobility (EPM) methods. The composition of the ternary microgels confirmed by IR spectroscopy.