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Updated: Mar 8, 2026

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
Published on: July 3, 2025
Tumor-restraining fibroblasts emerge after chemotherapy specifically in responders
Krishnan K Mahadevan1, Raghu Kalluri2
1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Abstract:
In this issue of Cancer Cell, Ma et al. identify a neoadjuvant chemotherapy-induced population of PTGER3+ cancer-associated fibroblasts (CAFs) in patients with bladder cancer.1 These CAFs undergo lipid oxidation reprogramming and enhance CD8+ T cell function, facilitating tumor microenvironment remodeling and restraining tumor progression.
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