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Updated: Mar 8, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization

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Published on: November 16, 2016

Host Proteome Remodeling During Group A Streptococcus Skin Infection.

Concepcion Sanchez¹, Igor H Wierzbicki¹, Charlie F Bayne¹

¹Department of Pharmacology, University of California, San Diego, La Jolla, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA; Center for Microbiome Innovation, University of California San Diego, La Jolla, California, USA.

Molecular & Cellular Proteomics : MCP

|March 6, 2026

Summary

Group A Streptococcus (GAS) skin infections cause complex immune responses. This study reveals chitinase-like proteins and distinct mTOR/kinase signaling in local versus systemic tissues.

Keywords:

chitinase-like proteins group A Streptococcus phosphoproteomics proteomics

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Area of Science:

Microbiology
Immunology
Proteomics

Background:

Group A Streptococcus (Streptococcus pyogenes, GAS) is a significant human pathogen causing local and invasive diseases.
The temporal and spatial coordination of host immune and tissue responses during GAS infection is not well understood.

Purpose of the Study:

To comprehensively analyze host responses to GAS skin infection across multiple proteome levels.
To characterize local and distant tissue responses and identify novel infection mechanisms.

Main Methods:

Utilized a mouse model of GAS skin infection.
Performed multi-level proteomic analysis, including global proteomics, cytokine profiling, and phosphoproteomics.
Integrated proteomic data with signaling pathway analysis (mTOR, kinase signaling).

Main Results:

Mapped changes in innate and adaptive immune signaling pathways.
Identified robust, time-dependent expression of chitinase-like proteins correlating with immune cell infiltration.
Revealed divergent correlations between mTOR and kinase signaling in local versus systemic tissues.

Conclusions:

The study provides a systems-level understanding of host proteome remodeling during GAS skin infection.
Uncovered novel insights into immune cell infiltration and signaling pathway dynamics.
Highlights the importance of post-translational modifications in immuno-modulatory networks.