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Updated: Mar 8, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Safeguarding global anticoagulant supply and access
Bingwen Eugene Fan1, Jacques Kah Yee Tang2, Emmanuel J Favaloro3
1Department of Haematology, Tan Tock Seng Hospital, Singapore; KLARIS Precision Health Research Clinic, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Haematology, Northern Health, Epping, Victoria, Australia; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Abstract:
Anticoagulants are essential to health care, yet their global supply is inherently fragile. Reliance on animal-derived heparin creates vulnerability to contamination, animal disease, and logistical disruption, whereas synthetic alternatives like warfarin and direct oral anticoagulants face mounting manufacturing and geopolitical risks. The COVID-19 pandemic exposed how these intersecting threats can converge during a crisis, causing critical shortages. To build resilience, a systemic shift is required: developing nonanimal-derived anticoagulants, diversifying production geographically, establishing protected supply corridors, reducing high-carbon footprint manufacturing processes, and creating equitable allocation frameworks. Anticoagulants must be recognized as essential medical assets, necessitating sustained investment and international coordination to ensure reliable access for all health systems, particularly before the next pandemic or global shock.
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