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Related Experiment Video

Updated: Mar 8, 2026

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Structure, function, regulation, evolution, and therapeutic implications of PARP14.

Pulak Kar1, Nina Đukić2, Dragana Ahel2

  • 1Department of Biological Sciences, Sri Ramaswamy Memorial University-Andhra Pradesh, Amaravati 522240, India; ivan.ahel@path.ox.ac.uk pulak.k@srmap.edu.in.

Genes & Development
|March 6, 2026
PubMed
Summary
This summary is machine-generated.

ADP-ribosylation (ADPr) is a key posttranslational modification. PARP14, an ADP-ribosyl transferase (ART), regulates DNA repair and immunity, offering therapeutic potential in oncology and immunology.

Keywords:
ADP-ribosylationDNA damagePARPinfectioninterferon signalingubiquitin

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Area of Science:

  • Molecular Biology
  • Genomics
  • Immunology

Background:

  • ADP-ribosylation (ADPr) is a crucial posttranslational modification across all life domains.
  • Human ADP-ribosyl transferases (ARTs), particularly PARP14, are vital regulators of cellular processes.
  • PARP14 is implicated in antiviral defense, inflammation, DNA damage response, and genomic stability.

Purpose of the Study:

  • To provide a comprehensive overview of PARP14's fundamental and emerging biological features.
  • To highlight PARP14's structure, function, evolution, and roles in cellular homeostasis and disease.
  • To discuss recent therapeutic strategies targeting PARP14 in oncology and immunology.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Exploration of PARP14's molecular mechanisms and signaling pathways.
  • Analysis of PARP14's involvement in DNA replication stress and repair.

Main Results:

  • PARP14 plays a dynamic role in modulating DNA replication stress and DNA repair.
  • PARP14 functions at the critical intersection of genomic stability and immune regulation.
  • Emerging evidence points to PARP14's involvement in various cellular processes and diseases.

Conclusions:

  • A deeper understanding of PARP14's mechanistic functions is essential.
  • Targeting PARP14 presents promising therapeutic avenues for oncology and immunology.
  • Further research into PARP14's regulatory network can drive novel clinical strategies.