TREM2 in neurodegeneration and diseases

Area of Science:

• Neuroscience
• Immunology
• Cell Biology

Background:

• Triggering receptor expressed on myeloid cells 2 (TREM2) is a key microglial receptor in the central nervous system.
• TREM2 signaling influences neuroinflammation and neurodegeneration, critical processes in neurological disorders.
• Its role is particularly significant in Alzheimer's disease (AD) and Parkinson's disease (PD).

Purpose of the Study:

• To review the role and mechanistic implications of TREM2 in neurodegeneration and neuroinflammation.
• To focus specifically on the involvement of TREM2 in Alzheimer's disease and Parkinson's disease.
• To highlight recent preclinical advancements and support researchers and clinicians.

Main Methods:

• Literature review of preclinical studies on TREM2.
• Analysis of TREM2's downstream signaling pathways.
• Examination of TREM2's transcriptional regulation of genes involved in neurodegeneration.

Main Results:

• TREM2 signaling is a critical regulator of microglial function in the CNS.
• Dysregulation of TREM2 is implicated in the pathophysiology of AD and PD.
• Recent preclinical studies reveal novel insights into TREM2's mechanisms.

Conclusions:

• TREM2 plays a pivotal role in microglial responses to neurodegenerative conditions.
• Targeting TREM2 pathways holds potential for developing novel therapeutic strategies for AD and PD.
• Further research into TREM2 function is essential for advancing neurodegenerative disease treatment.