The association between Helicobacter pylori and osteoporosis: the mediating effect of inflammation
Yi Chen1, Guoli Ying2, Wei Yang1
1Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, China.
Background:
Osteoporosis, a widespread metabolic bone disorder, leads to diminished bone density, heightened susceptibility to fractures, and overall skeletal fragility. As the world's population continues to age, this condition has emerged as a pressing public health issue. Recent research has explored the possible link between Helicobacter pylori (H. pylori) infection and various systemic diseases beyond the stomach. Yet, the connection between H. pylori and osteoporosis remains hotly debated, with the exact biological mechanisms still unclear.
Methods:
The study recruited participants from Taizhou Hospital who underwent routine health evaluations, including hematological assessment, urea breath tests, and bone density evaluations using dual-energy X-ray absorptiometry. Logistic regression models were used to investigate the relationship between H. pylori infection and osteoporosis. Additionally, mediation analysis was performed to determine the potential mediating role of inflammation in this association.
Results:
Logistic regression analysis identified H. pylori infection as a risk factor for osteoporosis. A subsequent cohort study provided additional evidence that chronic H. pylori infection is associated with an increased risk of osteoporosis. Mediation analysis revealed that inflammatory responses partially mediate the association between H. pylori and osteoporosis.
Conclusion:
This study suggests that H. pylori infection may be associated with an elevated risk of osteoporosis in postmenopausal women, with inflammatory response potentially acting as a partial mediating pathway.
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