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Related Experiment Video

Updated: Mar 8, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

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Neoplastic Foot Ulcers: A Multicentre Retrospective Study.

Agata Janowska¹, Valentina Dini¹, Marco Romanelli¹

¹Dermatology, University of Pisa, Pisa, Italy.

International Wound Journal

|March 7, 2026

Summary

This summary is machine-generated.

Neoplastic foot ulcers, often misdiagnosed, were studied in 106 patients. Melanoma and non-melanoma skin cancers were common, frequently appearing as ulcerated nodules on the foot dorsum.

Keywords:

foot atypical ulcers melanoma neoplastic ulcer neoplastic wound non‐melanoma skin cancer

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Area of Science:

Dermatology
Oncology
Podiatry

Background:

Neoplastic foot ulcers present diagnostic challenges for specialists due to location and patient comorbidities.
Accurate diagnosis is often delayed, impacting patient outcomes.

Purpose of the Study:

To analyze the clinical and histological characteristics of neoplastic foot ulcers.
To identify common tumor types, clinical presentations, and locations of these ulcers.

Main Methods:

A multicentre, retrospective study of 106 patients with neoplastic foot ulcers over 5 years.
Evaluation of demographic data, clinical features, histological diagnoses, tumor onset, and ulcer site.
Statistical analysis using SPSS software.

Main Results:

The mean patient age was 70.15 years, with primary tumor ulceration being the most frequent cause.
The dorsum of the foot was the most common site (66%), with lesions often presenting as ulcerated nodules.
Histological diagnoses included melanoma (45), non-melanoma skin cancers (34), benign tumors (18), and rarer malignancies (9).
Significant correlations were found between histotype and clinical lesion type, and between age and histotype.

Conclusions:

Neoplastic foot ulcers exhibit distinct clinical and histological features.
Further prospective research is warranted to better understand and manage these challenging wounds.