Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bile acid pattern in human amniotic fluid.

G Délèze, G Paumgartner, G Karlaganis

    European Journal of Clinical Investigation
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Der Internist·2017
    Same author

    Archives of gynecology and obstetrics·2016
    Same author

    MRI evaluation of diastematomyelia and associated abnormalities.

    The neuroradiology journal·2013
    Same author

    Pneumosinus Dilatans Syndrome of the Sphenoid Sinus. A CT Evaluation.

    The neuroradiology journal·2013
    Same author

    The revised Swiss environmental protection law - Main innovations.

    Environmental science and pollution research international·2013
    Same author

    Clearance of atrazine in soil describing xenobiotic behavior.

    Environmental science and pollution research international·2013

    Fetal bile acid profiles differ from adults, with 3beta-hydroxy-5-cholenoic acid decreasing significantly near term. This suggests developing fetal liver function impacts bile acid metabolism during late gestation.

    Area of Science:

    • Biochemistry
    • Maternal-fetal medicine
    • Developmental biology

    Background:

    • Bile acids are crucial for digestion and metabolism.
    • Understanding fetal bile acid profiles is key to assessing liver function and development.
    • Significant changes in bile acid metabolism are expected during late gestation.

    Purpose of the Study:

    • To quantify individual bile acids in human amniotic fluid.
    • To investigate changes in bile acid composition throughout the third trimester.
    • To explore potential differences between fetal and adult bile acid metabolism.

    Main Methods:

    • Analysis of individual bile acids in 29 amniotic fluid samples.
    • Samples collected from women between 32 and 41 weeks of gestation.

    Related Experiment Videos

  • Quantification using chromatographic techniques (implied).

    • Main Results:

    • Total bile acid concentrations ranged from 0.4 to 4.8 mumol/l.
    • Cholic acid and chenodeoxycholic acid were major bile acids.
    • 3beta-hydroxy-5-cholenoic acid was present in all samples, decreasing from 39.8% to 20.2% near term.

    Conclusions:

    • Fetal bile acid profiles exhibit distinct characteristics compared to adults.
    • A significant reduction in 3beta-hydroxy-5-cholenoic acid near term suggests hepatic maturation.
    • These findings highlight dynamic changes in fetal bile acid metabolism during late pregnancy.