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Pediatric Reference Intervals for Complete Blood Count Parameters in Healthy Turkish Infants and Children

Ünsal Özgen1, Filiz Orhon2, Gonca Keskindemirci3

  • 1Medical Faculty, Department of Pediatrics, Division of Pediatrics Hematology Oncology, Ondokuz Mayıs University, Samsun, Türkiye.

International Journal of Laboratory Hematology
|March 7, 2026
PubMed

Insights

This study establishes crucial reference ranges for complete blood count (CBC) parameters in healthy Turkish children. These findings offer a vital resource for accurate pediatric hematological assessments nationwide.

Area of Science:

  • Pediatric Hematology
  • Clinical Pathology
  • Reference Range Establishment

Background:

  • Accurate reference ranges for complete blood count (CBC) parameters are essential for diagnosing and monitoring various pediatric health conditions.
  • Existing CBC reference ranges may not accurately reflect the diverse pediatric population in Türkiye.
  • Establishing region-specific reference intervals is critical for precise clinical interpretation.

Purpose of the Study:

  • To determine and provide comprehensive reference ranges for complete blood count (CBC) parameters in healthy children residing in Türkiye.
  • To establish age- and sex-stratified reference intervals for key hematological indicators.
  • To create a foundational dataset for improved pediatric hematological evaluations in Türkiye.

Main Methods:

  • A large cohort of 24,115 healthy children aged 1 month to 18 years were enrolled across 10 centers in Türkiye.
  • Complete blood count (CBC) measurements were systematically collected from participants attending Well Child Outpatient Clinics.
  • Data were analyzed to determine mean, median, and nonparametric reference intervals (2.5th-97.5th percentile) stratified by age and sex.

Main Results:

  • The study presents mean and median values for red blood cell, white blood cell, and platelet parameters across various pediatric age groups.
  • Nonparametrically determined CBC reference intervals (RIs) for the 2.5th to 97.5th percentile were provided, stratified by age and sex.
  • Detailed hematological data were compiled for a large, diverse population of healthy Turkish children.

Conclusions:

  • This research provides the first established reference ranges for hematological parameters specifically for Turkish children under 18 years of age.
  • The generated reference intervals offer a more reliable and accurate basis for hematological evaluations in pediatric healthcare across Türkiye.
  • These findings will support clinicians in the precise interpretation of CBC results, enhancing diagnostic accuracy and patient care.
Abstract

Keywords:
Turkish infant and childrencomplete blood countreference value

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