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Related Experiment Video

Updated: Mar 8, 2026

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
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MR Radiomics Combined With Radiologic Features to Predict Recurrence Location in Nonviable Hepatocellular Carcinoma

Shuhang Zhang1, Weilang Wang1, Wu Cai2

  • 1Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, School of Medicine, Southeast University, Nanjing, China.

Journal of Gastroenterology and Hepatology
|March 7, 2026
PubMed
Summary

A new fusion model combining radiomics and radiologic features accurately predicts early recurrence locations in nonviable hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). This approach aids in personalized follow-up and retreatment planning for HCC patients.

Keywords:
hepatocellular carcinomaprognosisradiomicstransarterial chemoembolization

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging Analysis

Background:

  • Hepatocellular carcinoma (HCC) recurrence after transarterial chemoembolization (TACE) is common.
  • Identifying early recurrence locations is crucial for effective patient management.

Purpose of the Study:

  • To develop and evaluate a predictive model integrating radiomics and radiologic features for early recurrence site identification in nonviable HCC post-TACE.
  • To compare the performance of a fusion model against standalone radiomics and radiologic models.

Main Methods:

  • A multicenter retrospective study involving HCC patients treated with TACE.
  • Radiomics features were extracted from a 1-cm peritumoral ring divided into eight sectors.
  • A fusion model combined radiomics features with nonsmooth margin and peritumoral hyperintensity.
  • Model performance was assessed using receiver operating characteristic (ROC) curves and the DeLong test.

Main Results:

  • The fusion model achieved superior performance compared to radiomics and radiologic models in the training cohort (AUC 0.843 vs. 0.771 and 0.787).
  • In the test cohort, the fusion model (AUC 0.774) outperformed the radiomics model (AUC 0.602) and showed comparable performance to the radiologic model (AUC 0.736).
  • The fusion model demonstrated statistically significant improvements in predictive performance.

Conclusions:

  • The developed fusion model effectively predicts early recurrence locations in nonviable HCC after TACE.
  • This model shows potential for supporting personalized follow-up strategies and optimizing retreatment planning for HCC patients.