Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.6K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.6K
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

878
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
878
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.1K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.1K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

1.5K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.5K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

1.7K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mental health impacts experienced by caregivers of people with Dravet syndrome: A systematic literature review.

Epilepsia·2026
Same author

Telehealth enabled neuropsychological testing (TENT): a new platform for examiner-led, digital cognitive assessment.

Journal of neurology·2026
Same author

Functionality of symptoms and interpersonal communication in home video recordings of functional/dissociative versus epileptic seizures.

Epilepsia·2026
Same author

How Much Difference Does Depression Make to the Outcome of Neuropsychological Assessments of Patients With Epilepsy?

European journal of neurology·2026
Same author

Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE.

Epilepsia open·2026
Same author

Videoconference-integrated, computer-assisted cognitive testing improves the remote assessment of processing speed and attention.

Journal of the International Neuropsychological Society : JINS·2025
Same journal

Responsible use of artificial intelligence in peer-reviewed publications in epilepsy.

Epilepsia·2026
Same journal

Altered autonomic balance drives the increase in cardiac output and arterial pressure during convulsive seizures in nonanesthetized sheep.

Epilepsia·2026
Same journal

Diagnostic yield and copy number variants findings in 219 adult patients with developmental and epileptic encephalopathy.

Epilepsia·2026
Same journal

Prolonged fenfluramine use in open-label studies of Dravet or Lennox-Gastaut syndromes: Long-term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness.

Epilepsia·2026
Same journal

Electrocardiography characteristics and long-term mortality in people with epilepsy from a resource-poor community.

Epilepsia·2026
Same journal

Factors associated with rapid pediatric acute seizure emergency treatment: Quality Improvement in Time to Treat Status Epilepticus baseline cohort.

Epilepsia·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.9K

Executive dysfunction and employment in epilepsy.

Lisa E Hauger1,2, Christoph Helmstaedter3, Morten I Lossius1,2,4

  • 1Division for Clinical Neuroscience, National Centre for Epilepsy, Oslo University Hospital, Nydalen, Norway.

Epilepsia
|March 7, 2026
PubMed
Summary
This summary is machine-generated.

Executive dysfunction is common in epilepsy patients and linked to higher medication load and unemployment. Improving executive functions may be key to better employment outcomes in epilepsy care.

Keywords:
DREEpiTrackemploymentexecutive functionmental health

More Related Videos

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.7K
Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

10.1K

Related Experiment Videos

Last Updated: Mar 9, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.9K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.7K
Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

10.1K

Area of Science:

  • Neurology
  • Neuropsychology
  • Psychiatry

Background:

  • Epilepsy is frequently associated with executive dysfunction and affective symptoms.
  • The impact of these factors on employment and education participation remains unclear.

Purpose of the Study:

  • To investigate the relationship between epilepsy, executive functions (EFs), and affective symptoms.
  • To determine how these factors influence employment or education status.

Main Methods:

  • Retrospective study of 559 epilepsy patients.
  • EFs assessed using EpiTrack.
  • Affective symptoms evaluated using GAD-7 and NDDI-E.

Main Results:

  • Half of patients exhibited impaired EFs, associated with higher antiseizure medication (ASM) load.
  • 36% reported depression symptoms, 19% reported anxiety symptoms.
  • Unemployed patients showed significantly poorer EFs compared to those employed or in education.

Conclusions:

  • Executive dysfunction is prevalent in epilepsy patients, correlating with ASM load and unemployment.
  • Executive functioning plays a critical role in job retention beyond epilepsy burden.
  • Monitoring EF and minimizing ASM load are crucial for improving functional outcomes.