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Interaction Between Composite Dietary Antioxidant Index and Alcohol Consumption on Cardiovascular Diseases: NHANES

Yingjie Zhu1, Lili Zheng2, Jia Bing2

  • 1Jilin Provincial Institute of Population Life Science and Technology (Jilin Provincial Reproductive Health Hospital), Changchun, P. R. China.

Clinical Cardiology
|March 7, 2026
PubMed

Insights

The interaction between the Composite Dietary Antioxidant Index (CDAI) and alcohol consumption impacts cardiovascular disease (CVD) risk. Moderate alcohol intake with a high CDAI may lower CVD prevalence.

Area of Science:

  • Nutrition Science
  • Cardiology
  • Epidemiology

Background:

  • Cardiovascular diseases (CVDs) are the leading global cause of mortality.
  • Research on the combined effect of dietary antioxidants and alcohol on CVDs is limited.
  • Understanding these interactions is crucial for public health strategies.

Purpose of the Study:

  • To investigate the association between the Composite Dietary Antioxidant Index (CDAI) and CVDs.
  • To examine the role of alcohol consumption in relation to CVDs.
  • To determine if an interaction exists between CDAI and alcohol consumption concerning CVD risk.

Main Methods:

  • Analysis of data from 29,459 US adults (aged >20) from NHANES (2005-2018).
  • Calculation of CDAI based on six dietary factors.
  • Binary logistic regression and subgroup analyses to assess associations and interactions.

Main Results:

  • A significant interaction was observed between CDAI and alcohol consumption regarding CVD prevalence.
  • Increased CVD prevalence was noted in low CDAI groups (CDAI 1 and 2) among non-drinkers compared to moderate drinkers with high CDAI (CDAI 3).
  • Low CDAI levels were positively associated with higher CVD prevalence, particularly in individuals who never consumed alcohol.

Conclusions:

  • An interaction between CDAI and alcohol consumption significantly influences CVD risk.
  • Higher CDAI scores combined with moderate alcohol consumption appear to be associated with reduced odds of developing CVDs.
Abstract

Keywords:
NHANESalcohol consumptioncardiovascular diseases (CVDs)composite dietary antioxidant index (CDAI)oxidative stress

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