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Association Between Unsaturated Fatty Acid Levels and Chronic Obstructive Pulmonary Disease: A Bidirectional

Shuai Jiang1, Lili Lu2, Xiaojun Wang3

  • 1Department of Thoracic Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China.

The Clinical Respiratory Journal
|March 7, 2026
PubMed
Summary

Unsaturated fatty acids (UFAs) levels are causally linked to chronic obstructive pulmonary disease (COPD) risk. Higher levels of docosahexaenoic acid, linoleic acid, and omega fatty acids are associated with reduced COPD risk, while COPD liability increases monounsaturated fatty acid levels.

Keywords:
Mendelian randomization (MR)chronic obstructive pulmonary disease (COPD)risk factorsunsaturated fatty acids (UFAs)

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