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Updated: Oct 10, 2026
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
Borneol-Edaravone mitigates ischemic brain injury in MCAO rats
Xue-Feng Zhuang1, Tao Zhang1, Yue-Qin Zeng2
1College of Basic Medicine and First affiliated hospital, Kunming Medical University, Kunming, China.
Background:
Borneol-Edaravone, a derivative combining borneol and Edaravone, was evaluated for its neuroprotective and anti-inflammatory effects in a rat model of middle cerebral artery occlusion (MCAO), and its efficacy was compared with Edaravone alone.
Methods:
Borneol-Edaravone was administered intraperitoneally (IP) twice daily, starting at 6 h post-stroke induction and continuing for 7 days. Post-stroke outcomes, including sensorimotor function, neuroprotection, and inflammation markers were assessed.
Results:
As an anti-inflammatory agent(inhibited astrocyte and microglial overactivation, and reduced oxidative/nitrative stress markers (3-NT, 4-HNE), and its effectiveness in improving sensorimotor deficits and reduced cerebral infarct volume in the MCAO, Borneol-Edaravone demonstrated superior neuroprotection to Edaravone.
Conclusion:
These findings suggest that Borneol-Edaravone exerts both neuroprotective and anti-inflammatory effects and may offer enhanced protection with an extended therapeutic window from 4.5 to 6 h against cerebral ischemia-reperfusion injury compared to Edaravone.
