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Updated: Mar 9, 2026

Production and Detection of Reactive Oxygen Species ROS in Cancers

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

Harnessing reactive oxygen species for precision medicine: ROS-Activatable PROTACs for lung Cancer.

M Olazábal-Morán¹, C Blázquez-Barbadillo¹, E Pérez-Izquierdo¹

¹Nanocaging Research Group; Department of Biosciences; Faculty of Biomedical and Health Sciences; Universidad Europea de Madrid; Campus de Villaviciosa, Calle Tajo s/n, 28670, Villaviciosa de Odón, Madrid, España.

Advanced Drug Delivery Reviews

|March 7, 2026

Summary

Reactive oxygen species (ROS) have a dual role in lung cancer. ROS-activatable proteolysis-targeting chimeras (PROTACs) offer a promising new strategy to target cancer cells specifically, improving treatment effectiveness and safety.

Keywords:

Innovative therapy Lung Cancer Paradoxical role of ROS Precision medicine ROS-activatable PROTAC ROS-related SMIs ROS-related prodrugs Reactive oxygen species (ROS)

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Production and Detection of Reactive Oxygen Species ROS in Cancers

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Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

Area of Science:

Redox biology
Oncology
Chemical biology

Background:

Reactive oxygen species (ROS) are crucial in cellular signaling and can paradoxically promote or inhibit cancer. In lung cancer, dysregulated ROS contributes to tumor progression and treatment resistance.
Traditional ROS-modulating therapies for lung cancer have yielded inconsistent outcomes due to the complexity of redox biology and tumor heterogeneity.

Purpose of the Study:

To review the multifaceted roles of ROS in cancer, particularly lung cancer.
To examine current ROS-targeting strategies in lung cancer therapy.
To highlight the potential of ROS-activatable proteolysis-targeting chimeras (PROTACs) as an innovative therapeutic approach.

Main Methods:

Literature review integrating research on ROS in cancer, lung cancer therapeutics, and PROTAC technology.
Analysis of the mechanisms underlying ROS generation and signaling in cancer cells.
Evaluation of the design principles and potential applications of smart-PROTACs, specifically ROS-activatable PROTACs.

Main Results:

ROS exhibits a complex, context-dependent role in lung cancer, influencing DNA stability, signaling pathways, and drug resistance.
Existing ROS-targeting strategies face limitations due to biological complexity and tumor variability.
ROS-activatable PROTACs demonstrate potential for targeted cancer therapy by exploiting the tumor microenvironment's oxidative stress.

Conclusions:

ROS-activatable PROTACs represent a promising next-generation therapeutic strategy for lung cancer.
These agents leverage tumor-specific oxidative conditions for targeted protein degradation, potentially enhancing efficacy and reducing toxicity.
The integration of redox biology, chemical innovation, and precision oncology may lead to improved lung cancer treatments.