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Related Experiment Video

Updated: Mar 9, 2026

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Scleromyositis - The new frontier.

Marie Hudson1, Yves Troyanov2, Océane Landon-Cardinal3

  • 1Division of Rheumatology, Jewish General Hospital, McGill University, 3755 Côte Ste Catherine, Montreal, Quebec, H3T 1E2, Canada.

Best Practice & Research. Clinical Rheumatology
|March 7, 2026
PubMed
Summary

Systemic sclerosis (SSc) muscle involvement is a primary manifestation, not an overlap with autoimmune myositis (AIM). We propose the term scleromyositis (SM) to recognize this distinct condition and its unique features.

Keywords:
CapillaropathyCapillary basement membrane reduplicationMyopathyMyositisScleromyositisSerological gapSystemic sclerosisVasculopathy

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Area of Science:

  • Rheumatology
  • Immunology
  • Pathology

Background:

  • Muscle involvement is observed in systemic sclerosis (SSc).
  • Distinguishing SSc-associated muscle issues from other autoimmune myositis (AIM) is clinically challenging.
  • The underlying pathogenesis of muscle involvement in SSc requires further elucidation.

Purpose of the Study:

  • To review the clinical, serological, and pathological features of muscle involvement in SSc.
  • To differentiate SSc-associated muscle disease from AIM.
  • To propose a new term, scleromyositis (SM), for this entity and outline its pathogenic framework.

Main Methods:

  • Comprehensive literature review of SSc and AIM.
  • Analysis of clinical, serological, and pathological data.
  • Case study presentations illustrating unique features of SM.

Main Results:

  • Muscle involvement in SSc shares pathogenic mechanisms with other SSc organ manifestations.
  • SSc-associated muscle disease is proposed as a primary manifestation, termed scleromyositis (SM).
  • SM exhibits distinct characteristics differentiating it from AIM.

Conclusions:

  • Scleromyositis (SM) is a distinct clinical entity within systemic sclerosis (SSc).
  • Recognizing SM improves understanding of SSc pathogenesis and patient management.
  • Increased awareness and consistent use of the term scleromyositis are encouraged.