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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 20, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

Dissecting Tumor-Associated Tertiary Lymphoid Structure Formation and Maintenance Using Mouse Models.

Clémence Riffard¹, Zixi Yin¹, Kelli A Connolly¹

¹Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

Immunological Reviews

|March 8, 2026

Summary

This summary is machine-generated.

Tumor-associated tertiary lymphoid structures (TA-TLS) in the tumor microenvironment influence cancer prognosis and immunotherapy response. Mouse models are crucial for understanding TA-TLS formation, function, and therapeutic manipulation, advancing cancer research.

Keywords:

lymph node neoantigen preclinical models tertiary lymphoid structures tumor immunology

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Area of Science:

Immunology
Oncology
Cancer Research

Background:

Solid tumor microenvironments are complex systems with dynamic immune and non-immune cell interactions.
Tumor-associated tertiary lymphoid structures (TA-TLS) are linked to improved prognosis and immunotherapy response in various cancers.
Preclinical mouse models are vital for studying TA-TLS formation and function, offering temporal insights difficult to obtain in humans.

Purpose of the Study:

To review insights from mouse models regarding TA-TLS formation, persistence, and function in cancer.
To highlight experimental and technological advancements shaping future research in TA-TLS biology.
To explore the potential for therapeutic manipulation of TA-TLS in cancer treatment.

Main Methods:

Review of preclinical mouse models used to study TA-TLS.
Analysis of high-dimensional imaging and spatial profiling technologies.
Dissection of cellular interactions and mechanisms underlying TA-TLS development.

Main Results:

TA-TLS formation mirrors secondary lymphoid organogenesis but has unique initiation mechanisms.
TA-TLS can promote anti-tumor immunity but also harbor regulatory cells, indicating a dual role.
The resolution of TA-TLS and potential for local tissue memory remain areas for further investigation.

Conclusions:

Mouse models provide critical insights into TA-TLS biology, aiding in understanding their role in cancer.
Emerging technologies are shifting TA-TLS research towards mechanistic and functional understanding.
Further research is needed to elucidate TA-TLS initiation, therapeutic manipulation, and their long-term effects on anti-tumor immunity.