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Published on: July 26, 2019
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Neuronal VIP shapes intestinal stem cell activity and mucosal immunity
Camilla Anastasio1, Lucie Peduto1
1Stroma, Inflammation & Tissue Repair Unit, Institut Pasteur, Université Paris Cité, INSERM U1224, Paris, France.
Cell Stem Cell
|March 8, 2026
Summary
Neuronal vasoactive intestinal peptide (VIP) acts as a brake on intestinal stem cells (ISCs) by signaling through VIPR1. This pathway limits intestinal regeneration and balances immune responses, crucial for gut homeostasis.
Area of Science:
- Gastroenterology
- Immunology
- Stem Cell Biology
Background:
- Intestinal homeostasis and regeneration are critically dependent on intestinal stem cells (ISCs).
- Neuronal signals play a role in regulating ISC function and tissue repair.
- The interplay between the nervous system and the intestinal immune system is vital for gut health.
Purpose of the Study:
- To elucidate the role of neuronal vasoactive intestinal peptide (VIP) in regulating intestinal stem cell (ISC) activity.
- To investigate the mechanism by which VIP influences intestinal regeneration and lineage expansion.
- To understand how VIP-VIPR1 signaling impacts immune responses within the intestine.
Main Methods:
- Utilized genetic models to study VIP and VIPR1 function in the intestine.
- Employed lineage tracing and cell proliferation assays to assess ISC and secretory cell dynamics.
- Analyzed immune cell populations and cytokine profiles in response to VIP signaling modulation.
Main Results:
- Identified neuronal VIP as a key regulator that limits ISC proliferation and intestinal regeneration.
- Demonstrated that VIP signaling through VIPR1 restrains the expansion of secretory lineages.
- Showed that VIP-VIPR1 signaling contributes to balancing immune responses in the intestinal environment.
Conclusions:
- Neuronal VIP acts as a crucial brake on intestinal stem cell-driven regeneration via VIPR1.
- VIP-VIPR1 signaling is essential for controlling secretory cell numbers and maintaining immune homeostasis in the gut.
- This pathway represents a significant target for therapeutic interventions in intestinal diseases.
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