Related Experiment Video
Updated: Mar 9, 2026

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
Off-the-shelf CAR natural killer progenitor cell therapies are built to last
1Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Cellular Immunotherapy Program, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard Biological and Biomedical Sciences PhD Program, Boston, MA 02115, USA.
Abstract:
Induced pluripotent stem cell (iPSC)-derived chimeric antigen receptor (CAR) natural killer (NK) cells are an emerging class of off-the-shelf cellular immunotherapy limited by short-term persistence. Wang et al.1 develop a platform for lineage-committed progenitor cell therapy to sustain in vivo CAR iNK cell lymphopoiesis and enhance tumor control.
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