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Updated: Jul 5, 2026
Murine Fetal Echocardiography
Published on: February 15, 2013
Prospective Evaluation of Automated Right and Left Ventricular Myocardial Performance Index in Late-Onset Fetal
Gulnihal Reyhan Toptas1, Fatma Doga Ocal1, Burcu Bozkurt Ozdal1
1Perinatology Department, Ankara Bilkent City Hospital, Ankara, Turkey.
Objectives:
To evaluate automated right- and left-ventricular myocardial performance index (Mod-MPI) using the Samsung Hera W10 (MPI+™) system in fetuses with late-onset fetal growth restriction (FGR) and to explore its association with Doppler parameters and perinatal outcomes.
Methods:
This prospective study included 177 singleton pregnancies between 32 and 39 weeks of gestation-87 with late-onset FGR and 90 gestational-age-matched controls. Fetal echocardiography and Doppler examinations were performed using the Samsung Hera W10 system with integrated MPI+™ software. Automated right and left Mod-MPI, atrioventricular valve E/A ratios, and Doppler indices were recorded. Neonatal outcomes were analyzed in relation to MPI measurements.
Results:
Right-ventricular MPI and isovolumic contraction time (ICT) were significantly increased in FGR fetuses compared with controls (p = .001), whereas left-ventricular MPI showed no significant difference. Umbilical artery PI and RI were higher, and CPR and umbilical peak systolic velocity were lower in FGR. Right-sided MPI correlated negatively with gestational age, birth weight, and Apgar scores.
Conclusion:
Automated right-ventricular Mod-MPI provides a reproducible, objective indicator of early cardiac dysfunction in late-onset FGR. Elevation of right-sided MPI and prolongation of contraction time may reflect early myocardial adaptation preceding classical Doppler deterioration.
