[Liver-bone axis: novel mechanisms and strategies for MAFLD regulation]

Bones not only play an important role in providing structural support in the human body but also play a critical role in regulating the pathophysiological processes of various organs by secreting specific cytokines (osteokines). Growing evidence confirms the existence of extensive and close interaction between the liver and bone, known as the liver-bone axis. The regulatory role of the liver-bone axis in chronic liver diseases offers a novel research concept, particularly for understanding the complex metabolic regulatory network of metabolic dysfunction-associated fatty liver disease (MAFLD). This paper summarizes the latest advances, elucidates the bidirectional regulatory effects, and explores the roles of key factors in the liver-bone axis in MAFLD progression.