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Updated: Mar 10, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
[Advances in clinical features, diagnosis, and treatment of pre-acute-on-chronic liver failure]
1Department of Infection, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 401336, China.
Abstract:
Acute-on-chronic liver failure is a severe syndrome characterized by a rapid decline in liver function and multiple organ failure, with rapid progression often already in the mid-to-late stage by the time it is clinically diagnosed in patients with chronic liver disease. Currently, there are no therapeutic drugs that are efficacious, and the short-to medium-term mortality rate is high. Some academics have proposed establishing a term, "pre-acute-on-chronic liver failure," to denote a transitional stage for patients prior to their progress to acute-on-chronic liver failure. Early-stage intervention has been shown to effectively improve patient prognosis. This review explores the diagnostic and therapeutic aspects of pre-acute-on-chronic liver failure from recent years, with the aim to improve clinicians'' understanding and promote early-stage prevention and treatment.
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