[The evolution of antimicrobial therapy for sepsis]

Area of Science:

• Critical care medicine
• Infectious diseases
• Pharmacology

Background:

• Sepsis is a life-threatening organ dysfunction with high mortality.
• Antimicrobial resistance poses a growing challenge to effective sepsis treatment.
• Evolving understanding of sepsis pathophysiology necessitates updated treatment strategies.

Purpose of the Study:

• To systematically review the evolution of anti-infective therapy for sepsis.
• To highlight key changes in sepsis management, including stewardship and precision medicine.
• To clarify misconceptions and propose future directions in sepsis treatment.

Main Methods:

• Systematic review of anti-infective therapy in sepsis.
• Analysis of epidemiological data and pathogen resistance trends.
• Examination of evidence-based medical data and clinical trial outcomes.

Main Results:

• Antimicrobial stewardship in sepsis has significantly evolved.
• Key areas of focus include timing, empirical selection, dosing, and de-escalation strategies.
• Emerging sepsis sub-phenotypes and AI-assisted decision-making are transforming care.

Conclusions:

• Past experiences provide valuable lessons for current sepsis management.
• A future path toward precision medicine in sepsis treatment is outlined.
• Continuous adaptation of anti-infective strategies is crucial for improving sepsis outcomes.