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Updated: May 12, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
[Qualitative Analysis of Precursor Substances of Phenyl-2-Acetone and 3, 4-Methylenedioxyphenyl-2-Acetone]
Xue-Yan Liu1, Wei Jia2, Cui-Mei Liu2
1School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Objectives:
To optimize and establish GC-MS, LC-MS, and infrared spectroscopy (IR) methods for analyzing 1-phenyl-2-propanone (P-2-P) and 3,4-methylenedioxyphenyl-2-propanone (MDP-2-P) precursors.
Methods:
Eleven precursor substances of P-2-P and MDP-2-P were analyzed by GC-MS, LC-MS and IR methods, some key analytical parameters, such as solvent and injection temperature, were optimized.
Results:
Substances such as 3-oxo-2-phenylbutyl methyl ester (MAPA) contain ester bonds in their structures were prone to ester exchange reactions. Therefore, alcohol solvent should be avoided to prevent the esterification. Instead, non-alcohol solvents, such as acetonitrile, were recommended. Substances such as MAPA that may undergo decomposition at the gas phase injection port temperature exceeded 170 ℃. It was recommended to lower the temperature of the injection port to 170 ℃. For substances that did not show peaks during GC-MS analysis, such as 2-methyl-3-phenylglycidic acid sodium salt (BMK sodium glycidylate) and 2-methyl-3-[3,4-(methylenedioxy)phenyl]glycidic acid sodium salt(PMK sodium glycidylate), it was recommended for IR detection.
Conclusions:
This study established GC-MS, LC-MS and IR methods that can accurately qualitatively analyze eleven P-2-P and MDP-2-P precursors, which can provide technical support for the detection of such substances in related cases.
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