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Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
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Intranasal adrenaline: A new treatment for anaphylaxis
Kyohei Takahashi1, Noriyuki Yanagida1, Sakura Sato1
1Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
Summary
Needle-free intranasal adrenaline offers a breakthrough for pediatric anaphylaxis management. This innovative approach overcomes injection barriers, providing rapid and effective symptom relief for children with severe allergies.
Area of Science:
- Allergy and Immunology
- Pediatric Emergency Medicine
- Pharmaceutical Technology
Background:
- Pediatric anaphylaxis management is hindered by needle phobia and challenges with intramuscular adrenaline auto-injectors.
- Intramuscular injections can lead to suboptimal adrenaline delivery in children.
Purpose of the Study:
- To review current evidence on intranasal adrenaline formulations for pediatric anaphylaxis.
- To evaluate clinical efficacy, technology, and safety profiles of novel intranasal products.
Main Methods:
- Synthesis of current evidence on intranasal adrenaline formulations.
- Examination of three leading intranasal products: neffy®, UTULY™, and FMXIN002.
- Review of pharmacokinetic and clinical study data.
Main Results:
- Intranasal adrenaline shows comparable or superior plasma concentrations to intramuscular injections with faster absorption.
- A Phase 3 study demonstrated rapid symptom resolution (median 16 min) with no serious adverse events.
- Nasal congestion may enhance, not impair, adrenaline absorption, addressing delivery concerns.
Conclusions:
- Intranasal adrenaline formulations are a transformative advancement for anaphylaxis management, especially in pediatrics.
- Needle-free delivery eliminates injection barriers, simplifies administration, and offers enhanced stability.
- These formulations promise improved therapeutic efficacy and patient acceptance in managing severe allergic reactions.
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