Related Experiment Video
Updated: Mar 10, 2026
08:31
Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells
Published on: February 18, 2016
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Crooke Cell Adenoma: Is Its Aggressiveness Overestimated? Evidence From a Single-Centre Experience
Ilkin Muradov1, Serdar Sahin1,2, Sumeyye Akpinar3
1Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Clinical Endocrinology
|March 8, 2026
Summary
Crooke cell adenomas (CCAs) show similar remission and recurrence rates to other Cushing's disease types. However, CCAs present with larger tumors and more residual disease, necessitating vigilant long-term monitoring.
Area of Science:
- Endocrinology
- Oncology
- Pituitary Disorders
Background:
- Crooke cell adenomas (CCAs) are rare, potentially aggressive variants of corticotroph adenomas.
- Limited data exists on the clinical behavior of CCAs.
Purpose of the Study:
- To compare clinical, biochemical, radiological, and surgical outcomes of patients with CCAs versus non-CCA Cushing's disease (CD).
Main Methods:
- Retrospective analysis of patients with CD at a tertiary Pituitary Centre.
- Comparison of clinical presentation, biochemical markers, tumor size, Ki-67 index, remission, recurrence, and residual tumor rates between CCA and non-CCA groups.
Main Results:
- CCAs had higher baseline ACTH levels than non-CCAs.
- Tumor size and Ki-67 proliferation index were higher in CCAs.
- Remission and recurrence rates were comparable, but residual pituitary lesions were more frequent in CCAs.
Conclusions:
- CCAs may not be as aggressive as previously thought regarding biochemical remission and recurrence.
- Larger tumor size, higher proliferative index, and increased residual disease in CCAs highlight the need for careful long-term follow-up.
- Further multicenter studies are needed to fully characterize CCA clinical course.
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