Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

998
Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
998
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

3.4K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
3.4K
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

753
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
753
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

553
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
553
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

1.1K
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
1.1K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

695
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
695

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuing Vs. Withholding Home Beta-Blockers at Admission for Suspected Infection: A Target Trial Emulation.

Critical care medicine·2026
Same author

Catheter ablation of epicardial premature ventricular complexes in patients with and without cardiac scar.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Bachmann's Bundle-Related Atrial Tachycardias Following Catheter Ablation of Persistent Atrial Fibrillation.

Journal of cardiovascular electrophysiology·2026
Same author

Very High-Power Short-Duration Ablation for Premature Ventricular Complexes From Sites With Suboptimal Catheter Stability.

Journal of cardiovascular electrophysiology·2026
Same author

Multicenter Study on the Safety of Pulsed Field Ablation in Over 40,000 Patients: MANIFEST-US.

Journal of the American College of Cardiology·2025
Same author

Intersection of bioengineering and arrhythmia therapy.

Heart rhythm·2025

Related Experiment Video

Updated: Mar 10, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

26.9K

Patients Experiencing Unsuccessful Defibrillation From Implantable Cardiac Devices Remain at Elevated Risk Despite

Nathaniel Christian-Miller1, Muazzum Shah1, Kelly Arps1

  • 1Division of Cardiovascular Medicine, Department of Electrophysiology, University of Michigan, Ann Arbor, Michigan, USA.

Journal of Cardiovascular Electrophysiology
|March 9, 2026
PubMed
Summary

Failed defibrillation therapy in patients with implantable cardiac defibrillators (ICDs) occurred in 2.8% of cases. Both operative and non-operative management strategies yielded similar long-term outcomes, though repeat failures remained high.

More Related Videos

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

8.6K
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

3.0K

Related Experiment Videos

Last Updated: Mar 10, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

26.9K
Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

8.6K
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

3.0K

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Unsuccessful defibrillation therapy in patients with implantable cardiac defibrillators (ICDs) can stem from patient or device factors.
  • Management strategies following failed defibrillation therapy require further elucidation.

Purpose of the Study:

  • To investigate the management approaches and outcomes for patients experiencing unsuccessful defibrillation therapies with implantable cardiac devices.
  • To compare operative versus non-operative management strategies in this patient cohort.

Main Methods:

  • A single-center cohort study included patients with ICDs who experienced unsuccessful defibrillation therapies.
  • Demographic and device characteristics were analyzed.
  • Survival free from recurrent unsuccessful device therapy was assessed for patients managed operatively versus non-operatively.

Main Results:

  • Out of 1449 patients with ICDs, 40 (2.8%) had unsuccessful defibrillation therapies.
  • Management included device reprogramming, anti-arrhythmic drugs, conservative therapy, lead addition, or pulse generator change.
  • After a mean follow-up of 2.4 years, 55% experienced recurrent VT, with 15% having repeat failed defibrillator therapy.
  • No significant difference in recurrent failed shocks was observed between operative and non-operative management groups.

Conclusions:

  • The incidence of failed defibrillation therapy in ICD patients was 2.8%.
  • Both operative and non-operative management approaches resulted in comparable long-term outcomes.
  • A significant proportion (15%) of patients experienced repeat failed defibrillation therapy, indicating a persistent challenge.