Enhanced Postablative Laser Skin Healing with a Regenerative Skincare Formulation: a Comparative Randomized...

Laser resurfacing, with erbium-doped yttrium aluminum garnet (Erbium:YAG) lasers, is a leading treatment for photoaging owing to its relatively rapid healing profile. However, even with advanced technology, there remains a need for adjunctive topical treatments to enhance skin recovery, mitigate postprocedure pigmentation issues, and minimize postprocedure downtime.

This randomized, evaluator-blinded, controlled study evaluated a regenerative cream's performance following laser treatment. The study utilized a mini-zone model on the volar forearms of healthy participants to compare the cream's efficacy against laser treatment alone. Clinical and instrumental assessments were utilized to assess the efficacy of the regenerative cream in accelerating skin healing post laser.

Within 7 days of treatment, the regenerative cream significantly improved skin hydration (76%, p < 0.05) and smoothness (10%, p < 0.05), reduced skin roughness, crusting/scaling (49%, p < 0.05), and visual skin uniformity (49%, p < 0.05), compared with laser treatment alone. In addition, the regenerative cream showed greater reduction in skin redness (-27%, p < 0.05) than laser alone at day 18 post laser. Moreover, the regenerative cream outperformed an anhydrous benchmark formula in hydration, skin smoothness, and roughness after just 7 days.

These findings highlight the potential of the regenerative cream as a valuable addition to laser resurfacing procedures, promoting faster healing with improved aesthetic outcomes.