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Updated: Mar 10, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Ammonia: a metabolic checkpoint for Treg potency
Ali Valipour Motlagh1, Eyad Elkord2, Weiwei Dai3
1Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Ren'ai Road, Suzhou, Jiangsu 215123, People's Republic of China; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology (ISMIB), University of Liverpool, Liverpool, UK.
Abstract:
Ammonia acts as a metabolic checkpoint fueling regulatory T cells (Tregs). Gu et al. demonstrate that utilizing argininosuccinate lyase-linked survival buffering and a FOXP3-spermine-PPARγ axis for mitochondrial reinforcement allows Tregs to convert toxic waste into suppressive power, driving tumor immune evasion and immunotherapy resistance.

