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Updated: Mar 10, 2026
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Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
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Oral JAK Inhibitors as a Promising Therapeutic Strategy for Refractory Rosacea: A Systematic Review and Meta-Analysis
Yu Peng1, Mingzi Sun1, Jiayu Chen1
1The Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing, China.
Journal of Cosmetic Dermatology
|March 9, 2026
Summary
Oral Janus kinase (JAK) inhibitors show promise for treating difficult rosacea cases. Further research is needed to confirm their effectiveness and safety in larger patient groups.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Research
Background:
- Rosacea is a chronic inflammatory skin condition with limited treatment options for severe cases.
- Refractory rosacea subtypes present a significant therapeutic challenge for clinicians.
- Oral Janus kinase (JAK) inhibitors are being explored as novel treatments for rosacea.
Conclusions:
- Oral JAK inhibitors demonstrate encouraging potential for managing refractory rosacea.
- Current evidence is based on small sample sizes and requires validation.
- Large-scale randomized controlled trials are essential to confirm efficacy and guide treatment strategies.
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